Article
A novel isoform of platelet glycoprotein Ib alpha is prevalent in African Americans.
American journal of hematology - 1 Jan 1999
Aramaki K M, Reiner A P
Abstract excerpt
The heavy chain of platelet glycoprotein Ib (GPIb) contains two prevalent sequence polymorphisms. The first, Thr/Met145 is responsible for the human platelet alloantigen system, human platelet antigen (HPA)-2. The second is a tandem repeat polymorphism that consists of four variants, A, B, C, and D. Previous linkage studies in Caucasian and Eastern Asian populations have demonstrated that HPA-2a (Thr145) is...
Topics
- Alleles
- Antigens, Human Platelet
- Asian People
- Black People
- Gene Frequency
- Genetic Linkage
- Genotype
- Humans
- Minisatellite Repeats
- Platelet Glycoprotein GPIb-IX Complex
- Protein Isoforms
- Washington
- White People
- Black or African American
