The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease.

doi:10.1182/blood-2003-05-1502

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Article

The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease.

Blood - 1 Feb 2004

Afshar-Kharghan Vahid, Matijevic-Aleksic Nevenka, Ahn Chul, Boerwinkle Eric, Wu Kenneth K, López José A

Abstract excerpt

Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibalpha, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibalpha and the frequency of...

Topics

Alleles
Black People
Cohort Studies
Coronary Disease
Female
Genotype
Humans
Male
Middle Aged
Minisatellite Repeats
Platelet Glycoprotein GPIb-IX Complex
Risk Factors
White People
Black or African American

Source

Open in PubMed

Identifiers

PMID: 14592833
DOI: 10.1182/blood-2003-05-1502

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