Article
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.
Cell - 13 Jan 1995
Navas T A, Zhou Z, Elledge S J
Abstract excerpt
Inhibition of DNA synthesis induces transcription of DNA damage-inducible genes and prevents mitotic entry through the action of the S phase checkpoint. We have isolated a mutant, dun2, defective for both of these responses. DUN2 is identical to POL2, encoding DNA polymerase epsilon (pol epsilon). Unlike sad1 mutants defective for multiple cell cycle checkpoints, pol2 mutants are defective only for the S phase...
Topics
- Alleles
- Amino Acid Sequence
- DNA Damage
- DNA Polymerase II
- DNA Replication
- DNA-Directed DNA Polymerase
- Genetic Complementation Test
- Interphase
- Mitosis
- Molecular Sequence Data
- Mutation
- Phenotype