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Article

Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2003

Balasubramaniam Vivek, Tang Jen-Ruey, Maxey Anne, Plopper Charles G, Abman Steven H

Abstract excerpt

In addition to its vasodilator properties, nitric oxide (NO) promotes angiogenesis in the systemic circulation and tumors. However, the role of NO in promoting normal lung vascular growth and its impact on alveolarization during development or in response to perinatal stress is unknown. We hypothesized that NO modulates lung vascular and alveolar growth and that decreased NO production impairs distal lung growth...

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Source

Identifiers

PMID: 12588707
DOI: 10.1152/ajplung.00421.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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