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Article

APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010

Bekris Lynn M, Galloway Nichole M, Montine Thomas J, Schellenberg Gerard D, Yu Chang-En

Abstract excerpt

Currently the epsilon4 allele of the apolipoprotein E gene (APOE) is the strongest genetic risk factor for late onset Alzheimer's disease (AD). However, inheritance of the APOE epsilon4 allele is not necessary or sufficient for the development of AD. Genetic evidence suggests that multiple loci in a 70 kb region surrounding APOE are associated with AD risk. Even though these loci could represent surrogate markers...

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Source

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Identifiers

PMID: 19554612
DOI: 10.1002/ajmg.b.30993
PMCID: PMC2829359

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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