Article
ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain.
American journal of medical genetics - 8 Apr 2002
Myllykangas Liisa, Polvikoski Tuomo, Reunanen Karoliina, Wavrant-De Vrieze Fabienne, Ellis Clare, Hernandez Dena, Sulkava Raimo, Kontula Kimmo, Verkkoniemi Auli, Notkola Irma-Leena, Hardy John, Perez-Tur Jordi, Haltia Matti J, Tienari Pentti J
Abstract excerpt
ApoE epsilon4 allele increases the risk of late-onset Alzheimer disease (AD) as well as the amount of beta-amyloid deposition in the brain. Because half of AD patients do not have ApoE epsilon4, it is important to search for other determinants of ApoE that modify AD risk. We tested whether the haplotype background of the most common ApoE allele, epsilon3, influences brain amyloid deposition or the risk of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.