Article
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Lescai Francesco, Chiamenti Andrea Maria, Codemo Alessandra, Pirazzini Chiara, D'Agostino Giuseppe, Ruaro Cristina, Ghidoni Roberta, Benussi Luisa, Galimberti Daniela, Esposito Federica, Marchegiani Francesca, Cardelli Maurizio, Olivieri Fabiola, Nacmias Benedetta, Sorbi Sandro, Tagliavini Fabrizio, Albani Diego, Martinelli Boneschi Filippo, Binetti Giuliano, Santoro Aurelia, Forloni Gianluigi, Scarpini Elio, Crepaldi Gaetano, Gabelli Carlo, Franceschi Claudio
Abstract excerpt
This paper addresses a tenet of the literature on APOE, i.e., the relationship between the effects of the ε4, one of the established genetic risk factor for Alzheimer's disease (AD), and its expression levels as determined by APOE promoter polymorphisms. Five polymorphisms (-491 rs449647, -427 rs769446, -219 rs405509, and ε rs429358-) were studied in 1308 AD patients and 1082 control individuals from the...