Article
Polymorphism within the glutathione S-transferase P1 gene is associated with increased susceptibility to childhood malignant diseases.
Pediatric blood & cancer - 1 Oct 2004
Zielińska Elzbieta, Zubowska Małgorzata, Bodalski Jerzy
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are involved in the metabolism of carcinogens and anticancer drugs. Functional polymorphisms exist in at least three genes that code for the GSTs, such as the GSTM1 and GSTT1 gene deletions or the A-G transition within the GSTP1 gene, which represents distinct GSTP1a and GSTP1b alleles. In the present case-control study, we aimed at estimation of the relationship...
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