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Article

Association of A(313)G glutathione S-transferase P1 germline polymorphism with susceptibility to de novo myelodysplastic syndrome.

Leukemia & lymphoma - 1 Aug 2013

Zachaki Sophia, Stavropoulou Chrysa, Kalomoiraki Marina, Koromila Theodora, Daraki Aggeliki, Manola Kalliopi N, Mavrou Ariadni, Kanavakis Emmanuel, Pantelias Gabriel E, Sambani Constantina

Abstract excerpt

Models for the pathogenesis of myelodysplastic syndrome (MDS) imply the role of individual genetic variations in genes involved in detoxification mechanisms. GSTP1 enzyme plays a key role in the biotransformation of a variety of carcinogens. The corresponding gene is subject to a single nucleotide polymorphism (A(313)G) leading to abolished enzyme activity. In order to evaluate whether the GSTP1 polymorphism...

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Identifiers

PMID: 23278642
DOI: 10.3109/10428194.2012.762647

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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