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Article

Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2001

Davies S M, Robison L L, Buckley J D, Tjoa T, Woods W G, Radloff G A, Ross J A, Perentesis J P

Abstract excerpt

PURPOSE: Glutathione S-transferase theta (GSTT1) and mu (GSTM1) genes are polymorphic, the genes being absent in approximately 15% and 50% of the population, respectively. Because glutathione S-transferases may be involved in the metabolism of chemotherapy drugs, we hypothesized that presence or absence of the genes may influence the outcome of treatment for childhood acute myeloid leukemia (AML). PATIENTS AND...

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Source

Identifiers

PMID: 11230469
DOI: 10.1200/JCO.2001.19.5.1279

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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