Article
Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.
The American journal of tropical medicine and hygiene - 1 Sept 2004
Fitness Jodene, Floyd Sian, Warndorff David K, Sichali Lifted, Mwaungulu Lorren, Crampin Amelia C, Fine Paul E M, Hill Adrian V S
Abstract excerpt
We present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T-->C change in codon 352 of the vitamin D receptor gene appeared to be at high risk (odds ratio [OR] = 4.3, 95% confidence...
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