Article
Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations.
PLoS neglected tropical diseases - 1 Aug 2021
Bezerra Ohanna Cavalcanti de Lima, Alvarado-Arnez Lucia Elena, Mabunda Nédio, Salomé Graça, de Sousa Amina, Kehdy Fernanda de Souza Gomes, Sales-Marques Carolinne, Manta Fernanda Saloum de Neves, Andrade Rafaela Mota, Ferreira Laís Pereira, Leal-Calvo Thyago, Cardoso Cynthia Chester, Nunes Kelly, Gouveia Mateus H, Mbulaiteve Sam M, Yeboah Edward D, Hsing Ann, Latini Ana Carla Pereira, Leturiondo André Luiz, Rodrigues Fabíola da Costa, Noronha Ariani Batista, Ferreira Cynthia de Oliveira, Talhari Carolina, Rêgo Jamile Leão, Castellucci Léa Cristina de Carvalho, Tarazona-Santos Eduardo, Carvalho Elizeu Fagundes de, Meyer Diogo, Pinheiro Roberta Olmo, Jani Ilesh V, Pacheco Antonio Guilherme, Moraes Milton Ozório
Abstract excerpt
Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations for PK deficiency, which leads to hemolytic anemia, are associated with resistance to malaria in sub-Saharan Africa and with susceptibility to intracellular pathogens in experimental models. In this case-control study, we enrolled 4,555 individuals and...
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