Article
Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.
The Journal of infectious diseases - 1 May 2011
Alter Andrea, Huong Nguyen Thu, Singh Meenakshi, Orlova Marianna, Van Thuc Nguyen, Katoch Kiran, Gao Xiaojiang, Thai Vu Hong, Ba Nguyen Ngoc, Carrington Mary, Abel Laurent, Mehra Narinder, Alcaïs Alexandre, Schurr Erwin
Abstract excerpt
Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families....
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