Article
Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.
The American journal of tropical medicine and hygiene - 1 Dec 2001
Meisner S J, Mucklow S, Warner G, Sow S O, Lienhardt C, Hill A V
Abstract excerpt
Twin and family studies indicate that host genetic factors influence susceptibility to leprosy and, possibly, leprosy type. Murine studies have suggested a role for the natural resistance-associated macrophage protein 1 (Nramp1) gene, which can influence cellular immune responses to intracellular pathogens. We evaluated a variation in the human homolog, NRAMP1, recently associated with tuberculosis susceptibility...
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