Genome-wide association study of leprosy in Malawi and Mali.

doi:10.1371/journal.ppat.1010312

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Article

Genome-wide association study of leprosy in Malawi and Mali.

PLoS pathogens - 1 Sept 2022

Gilchrist James J, Auckland Kathryn, Parks Tom, Mentzer Alexander J, Goldblatt Lily, Naranbhai Vivek, Band Gavin, Rockett Kirk A, Toure Ousmane B, Konate Salimata, Sissoko Sibiri, Djimdé Abdoulaye A, Thera Mahamadou A, Doumbo Ogobara K, Sow Samba, Floyd Sian, Pönnighaus Jörg M, Warndorff David K, Crampin Amelia C, Fine Paul E M, Fairfax Benjamin P, Hill Adrian V S

Abstract excerpt

Leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. Despite recent improvements in disease control, leprosy remains an important cause of infectious disability globally. Large-scale genetic association studies in Chinese, Vietnamese and Indian populations have identified over 30 susceptibility loci for leprosy. There is a significant burden of leprosy in Africa,...

Topics

Humans
Child
Genome-Wide Association Study
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Malawi
Mali
Leprosy
Inflammatory Bowel Diseases

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Nucleoside Transport Proteins

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PMID: 36121873
DOI: 10.1371/journal.ppat.1010312
PMCID: PMC9624411

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