Article
Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers.
The Journal of infectious diseases - 15 Oct 2004
El-Etr Sahar H, Mueller Anne, Tompkins Lucy S, Falkow Stanley, Merrell D Scott
Abstract excerpt
To extend our knowledge of host-cell targets of Helicobacter pylori, we characterized the interaction between H. pylori and human T84 epithelial cell polarized monolayers. Transcriptional analysis by use of human microarrays and a panel of isogenic H. pylori mutants revealed distinct responses to infection. Of the 670 genes whose expression changed, most (92%) required the cag pathogenicity island (PAI). Although...
Topics
- Antigens, Bacterial
- Bacterial Proteins
- Cell Line, Tumor
- Cell Polarity
- Cell Shape
- Gene Expression Regulation
- Helicobacter pylori
- Humans
- Microscopy, Confocal
- Mutation
- Oligonucleotide Array Sequence Analysis