Article
Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2005
Bagnoli Fabio, Buti Ludovico, Tompkins Lucy, Covacci Antonello, Amieva Manuel R
Abstract excerpt
CagA is a bacterial effector protein of Helicobacter pylori that is translocated via a type IV secretion system into gastric epithelial cells. We previously described that H. pylori require CagA to disrupt the organization and assembly of apical junctions in polarized epithelial cells. In this study, we provide evidence that CagA expression is not only sufficient to disrupt the apical junctions but also perturbs...
Topics
- Amino Acid Motifs
- Animals
- Antigens, Bacterial
- Bacterial Proteins
- Cell Adhesion
- Cell Line
- Cell Movement
- Cell Polarity
- Cell Transformation, Neoplastic
- Dogs
- Extracellular Matrix