Disruption of the Epithelial Apical-Junctional Complex by <i>Helicobacter pylori</i> CagA

doi:10.1126/science.1081919

Article

Disruption of the Epithelial Apical-Junctional Complex by <i>Helicobacter pylori</i> CagA

29 May 2003

Abstract excerpt

Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the...

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