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Article

Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma.

Oncogene - 28 Oct 2004

Umetani Naoyuki, Fujimoto Akihide, Takeuchi Hiroya, Shinozaki Masaru, Bilchik Anton J, Hoon Dave S B

Abstract excerpt

APAF-1 gene, located at chromosome locus 12q23, is a key factor in the mitochondrial apoptotic pathway downstream of p53, and is a potential tumor suppressor gene. We hypothesized that APAF-1 gene dysfunction due to allelic imbalance (AI) contributes to the development and progression of colorectal carcinoma (CRC). AI at APAF-1 locus and microsatellite instability (MIN) in CRCs and adenomas were assessed by...

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Share to Apoptotic Protease-Activating Factor 1
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15378005
DOI: 10.1038/sj.onc.1208022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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