Article
Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas.
Oncogene - 20 Sept 2001
Sugai T, Habano W, Uesugi N, Jiao Y F, Nakamura S I, Yoshida T, Higuchi T
Abstract excerpt
DNA multiploidy may involve specific DNA ploidy states with respect to genetic alterations such as oncogenes, tumor suppressor gene mutation and microsatellite instability. To clarify the role of DNA multiploidy in colorectal cancer, we analysed allelic imbalance involving the ATM gene, localized to chromosome 11q22-23 and thought to be involved in genetic stability, in a series of multiploid colorectal...
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