Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.

Gastroenterology - 1 Jun 2007

Chung Sun-Ku, Lee Min-Goo, Ryu Byung-Kyu, Lee Jin-Hee, Han Jikhyon, Byun Do-Sun, Chae Kwon-Seok, Lee Kil Yeon, Jang Jae-Young, Kim Hyo-Jong, Chi Sung-Gil

Abstract excerpt

BACKGROUND & AIMS: X-linked inhibitor of apoptosis protein-associated factor 1 (XAF1) is a candidate tumor suppressor located at the chromosome 17p13 region, but the molecular basis underlying its inactivation in human tumors and growth-inhibiting function has not been well defined. We explored t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Down-Regulation

Share to Gene Silencing

Share to Intracellular Signaling Peptides and Proteins

Share to Loss of Heterozygosity

Share to Stimulation, Chemical

Source

Identifiers

PMID: 17570219
DOI: 10.1053/j.gastro.2007.04.024

Genes

XAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17570219-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.PMID 17570219Read ↗

Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.Semantic proximity Read ↗

Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stressesSemantic proximity Read ↗

XAF1 Inactivation Increases Tumor Cell Resistance to Endoplasmic Reticulum Stress-Induced Apoptosis Through Stabilization of GRP78 and CHIPSemantic proximity Read ↗

XAF1 drives apoptotic switch of endoplasmic reticulum stress response through destabilization of GRP78 and CHIPSemantic proximity Read ↗

Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.Semantic proximity Read ↗

XIAP‐associated factor 1 (XAF1), a novel target of p53, enhances p53‐mediated apoptosis via post‐translational modificationSemantic proximity Read ↗

A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival.Semantic proximity Read ↗

The role of X-box binding protein-1 in tumorigenicitySemantic proximity Read ↗

Identification of a Germline XAF1 Mutation in Patients With Gastrointestinal Cancers.Semantic proximity Read ↗

Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.Semantic proximity Read ↗

XAF1 nonsense mutation rs117407731 enhances lung adenocarcinoma susceptibility via apoptosis suppression.Semantic proximity Read ↗

HAX‐1: A family of apoptotic regulators in health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.