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Article

Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.

Cancer research - 15 Sept 2004

Kaneda Atsushi, Wakazono Kuniko, Tsukamoto Tetsuya, Watanabe Naoko, Yagi Yukiko, Tatematsu Masae, Kaminishi Michio, Sugimura Takashi, Ushijima Toshikazu

Abstract excerpt

Lysyl oxidase (LOX) and HRAS-like suppressor (HRASLS) are silenced in human gastric cancers and are reported to have growth-suppressive activities in ras-transformed mouse/rat fibroblasts. Here, we analyzed whether or not LOX and HRASLS are tumor suppressor genes in human gastric cancers. Loss of heterozygosity and promoter methylation of LOX were detected in 33% (9 of 27) and 27% (26 of 96) of gastric cancers,...

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Share to Gene Expression Regulation, Enzymologic
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Mice, Inbred BALB C

Share to Phospholipases A

Share to Protein-Lysine 6-Oxidase

Share to Stomach Neoplasms

Source

Identifiers

PMID: 15374948
DOI: 10.1158/0008-5472.CAN-04-1543

Genes

LOX
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.PMID 15374948Read ↗

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