Article
Fractional allelic loss in gastric carcinoma correlates with growth patterns.
Oncogene - 19 Nov 1998
Choi S W, Park S W, Lee K Y, Kim K M, Chung Y J, Rhyu M G
Abstract excerpt
To gain an insight into the genetic events underlying morphological phenotypes, we analysed 58 gastric carcinoma tissues for the genome-wide allelotype study using microsatellite markers. Based on a binomial distribution, loss of heterozygosity (LOH) that was significantly more frequent than expected (P<0.05) thus interpreted as nonrandom LOH selected during tumorigenesis. The overall extent of chromosomes...
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