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Article

LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.

Cancer research - 1 May 2007

Wu Guojun, Guo Zhongmin, Chang Xiaofei, Kim Myoung Sook, Nagpal Jatin K, Liu Junwei, Maki Joni M, Kivirikko Kari I, Ethier Stephen P, Trink Barry, Sidransky David

Abstract excerpt

Promoter hypermethylation is one of the common mechanisms leading to gene silencing in various human cancers. Using a combination of pharmacologic unmasking and microarray techniques, we identified 59 candidate hypermethylated genes, including LOXL1, a lysyl oxidase-like gene, in human bladder cancer cells. We further showed that LOXL1 and LOXL4 are commonly silenced genes in human bladder cancer cells, and this...

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Source

Identifiers

PMID: 17456585
DOI: 10.1158/0008-5472.CAN-07-0012

Genes

LOXL1
LOXL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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