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Article

Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions.

World journal of gastroenterology - 14 Jan 2005

Li Yi-Ling, Tian Zhong, Wu Dong-Ying, Fu Bao-Yu, Xin Yan

Abstract excerpt

AIM: To investigate the loss of heterozygosity (LOH) and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions. METHODS: Thirty cases of normal gastric mucosa, advanced and early stage gastric cancer, intestinal metaplasia, atrophic gastritis, and atypical hyperplasia were analyzed for PTEN LOH and mutations within the entire coding region of PTEN gene by PCR-SSCP denaturing PAGE gel...

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Share to Chromosomes, Human, Pair 10
Share to Gastric Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Single-Stranded Conformational

Share to Precancerous Conditions

Share to PTEN Phosphohydrolase

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 15633233
DOI: 10.3748/wjg.v11.i2.285
PMCID: PMC4205419

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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