Article
Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas.
Japanese journal of cancer research : Gann - 1 Jun 1994
Ayhan A, Yasui W, Yokozaki H, Seto M, Ueda R, Tahara E
Abstract excerpt
The loss of heterozygosity (LOH) at the bcl-2 gene locus and the expression of the bcl-2 gene were examined in gastric and colorectal carcinoma cell lines and carcinoma tissues. LOH at the bcl-2 locus was detected in 24% (4/17) of gastric and 60% (6/10) of colonic carcinomas, all of which were we...
Topics
- Adenocarcinoma
- Blotting, Northern
- Cell Differentiation
- Colorectal Neoplasms
- Gene Deletion
- Gene Expression
- Genetic Variation
- Heterozygote
- Humans
- Lymphocytes
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- RNA, Messenger
- Stomach Neoplasms
- Tumor Cells, Cultured