Article
Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin.
Molecular biology of the cell - 1 Dec 2004
Krampert Monika, Bloch Wilhelm, Sasaki Takako, Bugnon Philippe, Rülicke Thomas, Wolf Eckhard, Aumailley Monique, Parks William C, Werner Sabine
Abstract excerpt
The matrix metalloproteinase stromelysin-2 is expressed in keratinocytes of the epithelial tongue of skin wounds, suggesting a role in keratinocyte migration. Here, we show that stromelysin-2 enhances migration of cultured keratinocytes. To gain insight into the in vivo activities of stromelysin-2 in epithelial repair, we generated transgenic mice expressing a constitutively active stromelysin-2 mutant in...
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