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Article

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.

Developmental biology - 1 May 2011

Gannon Hugh S, Donehower Lawrence A, Lyle Stephen, Jones Stephen N

Abstract excerpt

The p53 transcription factor is activated by various types of cell stress or DNA damage and induces the expression of genes that control cell growth and inhibit tumor formation. Analysis of mice that express mutant forms of p53 suggest that inappropriate p53 activation can alter tissue homeostasis and life span, connecting p53 tumor suppressor functions with accelerated aging. However, other mouse models that...

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Source

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Identifiers

PMID: 21334322
DOI: 10.1016/j.ydbio.2011.02.007
PMCID: PMC3075331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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