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Article

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

Nature genetics - 1 Nov 2003

Balbín Milagros, Fueyo Antonio, Tester Angus M, Pendás Alberto M, Pitiot Ana S, Astudillo Aurora, Overall Christopher M, Shapiro Steven D, López-Otín Carlos

Abstract excerpt

Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer. This may be partly because broad-range inhibitors also reduce host-protective antitumor properties of individual MMPs. We generated mice deficient in collagenase-2 (Mmp8), an MMP mainly produced by neutrophils in inflammatory reactions...

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PMID: 14517555
DOI: 10.1038/ng1249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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