Article
The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.
Arthritis and rheumatism - 1 Dec 1995
Christner P J, Peters J, Hawkins D, Siracusa L D, Jiménez S A
Abstract excerpt
OBJECTIVE: To describe the histopathologic and biochemical characteristics of skin from the Tsk2/+ mouse, a mutation with phenotypic features resembling those of systemic sclerosis (SSc), and to report the initial genetic mapping of the Tsk2 locus. METHODS: Histologic examination was performed an...
Topics
- Animals
- Chromosome Mapping
- Collagen
- Disease Models, Animal
- Female
- Fibrosis
- Leukocytes, Mononuclear
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Procollagen
- RNA, Messenger
- Scleroderma, Systemic
- Skin