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Article

The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.

Arthritis and rheumatism - 1 Dec 1995

Christner P J, Peters J, Hawkins D, Siracusa L D, Jiménez S A

Abstract excerpt

OBJECTIVE: To describe the histopathologic and biochemical characteristics of skin from the Tsk2/+ mouse, a mutation with phenotypic features resembling those of systemic sclerosis (SSc), and to report the initial genetic mapping of the Tsk2 locus. METHODS: Histologic examination was performed and collagen content and type I collagen messenger RNA (mRNA) levels were determined in skin biopsy specimens from Tsk2/+...

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Identifiers

PMID: 8849351
DOI: 10.1002/art.1780381212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.PMID 8849351Read ↗

The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2.Semantic proximity Read ↗

A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases.Semantic proximity Read ↗

Regulation of collagen gene expression in the Tsk2 mouse.Semantic proximity Read ↗

Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.Semantic proximity Read ↗

The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.Semantic proximity Read ↗

Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents.Semantic proximity Read ↗

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.Semantic proximity Read ↗

Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15.Semantic proximity Read ↗

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic SclerosisSemantic proximity Read ↗

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast TransitionSemantic proximity Read ↗

Marfan-like skeletal phenotype in the tight skin (Tsk) mouse.Semantic proximity Read ↗

Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative GenomicsSemantic proximity Read ↗

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