Article
Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2004
Bruno Martin A, Clarke Paul B S, Seltzer Alicia, Quirion Rémi, Burgess Kevin, Cuello A Claudio, Saragovi H Uri
Abstract excerpt
Previously, we developed a proteolytically stable small molecule peptidomimetic termed D3 as a selective ligand of the extracellular domain of the TrkA receptor for the NGF. Ex vivo D3 was defined as a selective, partial TrkA agonist. Here, the in vivo efficacy of D3 as a potential therapeutic for cholinergic neurons was tested in cognitively impaired aged rats, and we compared the consequence of partial TrkA...
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