Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Feb 2012

Allard Simon, Leon Wanda C, Pakavathkumar Prateep, Bruno Martin A, Ribeiro-da-Silva Alfredo, Cuello A Claudio

Abstract excerpt

Cortical cholinergic atrophy plays a significant role in the cognitive loss seen with aging and in Alzheimer's disease (AD), but the mechanisms leading to it remain unresolved. Nerve growth factor (NGF) is the neurotrophin responsible for the phenotypic maintenance of basal forebrain cholinergic neurons in the mature and fully differentiated CNS. In consequence, its implication in cholinergic atrophy has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinergic Neurons
Share to Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Degeneration

Share to Nerve Growth Factor

Share to Nerve Growth Factors

Share to Neural Pathways

Share to Protein Precursors

Share to Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 22323714
DOI: 10.1523/JNEUROSCI.1144-11.2012
PMCID: PMC6621687

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype.PMID 22323714Read ↗

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.Semantic proximity Read ↗

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.Semantic proximity Read ↗

Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex.Semantic proximity Read ↗

Development of a non invasive NGF-based therapy for Alzheimer's disease.Semantic proximity Read ↗

<i>TrkA</i>Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic CircuitrySemantic proximity Read ↗

Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.Semantic proximity Read ↗

Decreased Neurotrophic Support is Associated with Cognitive Decline in Non-Demented Subjects.Semantic proximity Read ↗

Muscular dystrophy in adult and aged anti-NGF transgenic mice resembles an inclusion body myopathy.Semantic proximity Read ↗

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.Semantic proximity Read ↗

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields.Semantic proximity Read ↗

Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy.Semantic proximity Read ↗

Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.