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Article

Paradoxical effect of TrkA inhibition in Alzheimer's disease models.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Zhang Qiang, Descamps Olivier, Hart Matthew J, Poksay Karen S, Spilman Patricia, Kane Darci J, Gorostiza Olivia, John Varghese, Bredesen Dale E

Abstract excerpt

An unbiased screen for compounds that block amyloid-β protein precursor (AβPP) caspase cleavage identified ADDN-1351, which reduced AβPP-C31 by 90%. Target identification studies showed that ADDN-1351 is a TrkA inhibitor, and, in complementary studies, TrkA overexpression increased AβPP-C31 and cell death. TrkA was shown to interact with AβPP and suppress AβPP-mediated transcriptional activation. Moreover,...

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Identifiers

PMID: 24531152
DOI: 10.3233/JAD-130017
PMCID: PMC4091737

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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