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Article

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.

Development (Cambridge, England) - 1 Oct 2004

Rana Amer Ahmed, Barbera Juan Pedro Martinez, Rodriguez Tristan A, Lynch Denise, Hirst Elizabeth, Smith James C, Beddington Rosa S P

Abstract excerpt

Dyneins have been implicated in left-right axis determination during embryonic development and in a variety of human genetic syndromes. In this paper, we study the recently discovered mouse dynein 2 light intermediate chain (mD2LIC), which is believed to be involved in retrograde intraflagella transport and which, like left-right dynein, is expressed in the node of the mouse embryo. Cells of the ventral node of...

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PMID: 15371312
DOI: 10.1242/dev.01389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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