Article
Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.
Nature - 30 Oct 1997
Supp D M, Witte D P, Potter S S, Brueckner M
Abstract excerpt
The development of characteristic visceral asymmetries along the left-right (LR) axis in an initially bilaterally symmetrical embryo is an essential feature of vertebrate patterning. The allelic mouse mutations inversus viscerum (iv) and legless (lgl) produce LR inversion, or situs inversus, in h...
Topics
- Amino Acid Sequence
- Animals
- Axons
- Body Patterning
- Chromosomes, Artificial, Yeast
- Conserved Sequence
- Dyneins
- Embryo, Mammalian
- Gene Expression
- Humans
- Mice
- Mice, Inbred Strains
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Situs Inversus