Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.

Nature - 30 Oct 1997

Supp D M, Witte D P, Potter S S, Brueckner M

Abstract excerpt

The development of characteristic visceral asymmetries along the left-right (LR) axis in an initially bilaterally symmetrical embryo is an essential feature of vertebrate patterning. The allelic mouse mutations inversus viscerum (iv) and legless (lgl) produce LR inversion, or situs inversus, in half of live-born homozygotes. This suggests that the iv gene product drives correct LR determination, and in its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Conserved Sequence
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 9353118
DOI: 10.1038/40140
PMCID: PMC1800588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.PMID 9353118Read ↗

Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.Semantic proximity Read ↗

Establishment of left-right asymmetry in vertebrates: genetically distinct steps are involved.Semantic proximity Read ↗

Formation and malformation of the vertebrate left-right axis.Semantic proximity Read ↗

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.Semantic proximity Read ↗

Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.Semantic proximity Read ↗

An unconventional myosin in Drosophila reverses the default handedness in visceral organs.Semantic proximity Read ↗

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.Semantic proximity Read ↗

Handed asymmetry in the mouse: understanding how things go right (or left) by studying how they go wrong.Semantic proximity Read ↗

Type ID unconventional myosin controls left-right asymmetry in Drosophila.Semantic proximity Read ↗

Of mice and men: dissecting the genetic pathway that controls left-right asymmetry in mice and humans.Semantic proximity Read ↗

The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness.Semantic proximity Read ↗

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.