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Article

Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits.

European journal of pharmacology - 19 Sept 2004

Klaasse Elisabeth, de Ligt Rianne A F, Roerink Sophie F, Lorenzen Anna, Milligan Graeme, Leurs Rob, IJzerman Ad P

Abstract excerpt

We studied fusion proteins between the human adenosine A1 receptor and different 351Cys-mutated G(i1) alpha-subunits (A1-Gialpha) with respect to two important concepts in receptor pharmacology, i.e. allosteric modulation and constitutive activity/inverse agonism. The aim of our study was twofold. We first analysed whether such fusion products are still subject to allosteric modulation, and, secondly, we...

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PMID: 15363955
DOI: 10.1016/j.ejphar.2004.07.108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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