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Article

Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors.

Current topics in medicinal chemistry - 1 Jun 2002

Teitler Milt, Herrick-Davis Katharine, Purohit Anil

Abstract excerpt

Several lines of evidence indicate that G-protein coupled receptors (GPCR) may exist in a state that allows a tonic level of stimulation in vivo (constitutive activity). Several native forms of GPCR, when expressed in recombinant cell lines, display significant signal transduction stimulation in the absence of activating ligand. Many GPCR, including three serotonin receptors, display robust constitutive...

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Source

Identifiers

PMID: 12052192
DOI: 10.2174/1568026023393859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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