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Article

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.

PloS one - 19 Dec 2007

Chang Wei Chun, Ng Jennifer K, Nguyen Trieu, Pellissier Lucie, Claeysen Sylvie, Hsiao Edward C, Conklin Bruce R

Abstract excerpt

G protein-coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs and the paucity of ligands with specific signaling effects. To better compare the effects of activating different G-protein signaling pathways through ligand-induced or...

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Identifiers

PMID: 18338032
DOI: 10.1371/journal.pone.0001317
PMCID: PMC2267039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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