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Article

A "locked-on," constitutively active mutant of the adenosine A1 receptor.

European journal of pharmacology - 7 Mar 2005

de Ligt Rianne A F, Rivkees Scott A, Lorenzen Anna, Leurs Rob, IJzerman Ad P

Abstract excerpt

We studied the wild-type human adenosine A1 receptor and three mutant receptors, in which the glycine at position 14 had been changed into an alanine, a leucine, or a threonine residue. All receptors were characterized in radioligand binding experiments, the wild-type and the Gly14Thr mutant receptor in greater detail. Both receptors were allosterically modulated by sodium ions and PD81,723...

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Identifiers

PMID: 15740718
DOI: 10.1016/j.ejphar.2005.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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