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Article

Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2.

The EMBO journal - 1 Oct 2004

Ritter Brigitte, Denisov Alexei Yu, Philie Jacynthe, Deprez Christophe, Tung Elaine C, Gehring Kalle, McPherson Peter S

Abstract excerpt

The adaptor proteins AP-2 and AP-1/GGAs are essential components of clathrin coats at the plasma membrane and trans-Golgi network, respectively. The adaptors recruit accessory proteins to clathrin-coated pits, which is dependent on the adaptor ear domains engaging short peptide motifs in the accessory proteins. Here, we perform an extensive mutational analysis of a novel WXXF-based motif that functions to mediate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15359277
DOI: 10.1038/sj.emboj.7600378
PMCID: PMC522786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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