Article
Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.
Molecular biology of the cell - 1 Jun 2003
Lui Winnie W Y, Collins Brett M, Hirst Jennifer, Motley Alison, Millar Caroline, Schu Peter, Owen David J, Robinson Margaret S
Abstract excerpt
The adaptor appendage domains are believed to act as binding platforms for coated vesicle accessory proteins. Using glutathione S-transferase pulldowns from pig brain cytosol, we find three proteins that can bind to the appendage domains of both the AP-1 gamma subunit and the GGAs: gamma-synergin and two novel proteins, p56 and p200. p56 elicited better antibodies than p200 and was generally more tractable....
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