Article
Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants.
The Journal of allergy and clinical immunology - 1 Sept 2004
Chen Weiguo, Ericksen Mark B, Levin Linda S, Khurana Hershey Gurjit K
Abstract excerpt
BACKGROUND: IL-13 is a key mediator of allergic asthma. IL-13 mediates its effects via its receptor, a heterodimer composed of IL-4R alpha and IL-13R alpha1. Polymorphic variants of both IL-13 and IL-4R alpha have been shown to be associated with atopy. OBJECTIVE: We examined the functional consequences of the Q110 IL-13 variant in vitro and in vivo to determine whether it displays enhanced functional activity...
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