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Article

IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma.

The Journal of allergy and clinical immunology - 1 Feb 2006

Kabesch Michael, Schedel Michaela, Carr David, Woitsch Bernd, Fritzsch Christian, Weiland Stephan K, von Mutius Erika

Abstract excerpt

BACKGROUND: IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects. OBJECTIVE: Here we analyzed combined extended haplotypes involving IL-4, IL-13, their shared receptor chain IL-4Ralpha, and the intracellular signal transducer and activator of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16461126
DOI: 10.1016/j.jaci.2005.10.024

Genes

STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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