Article
Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma.
Allergology international : official journal of the Japanese Society of Allergology - 1 Sept 2011
Nagashima Hiromi, Nakamura Yutaka, Kanno Hiroyuki, Sawai Takashi, Inoue Hiroshi, Yamauchi Kohei
Abstract excerpt
BACKGROUND: IL-13 is a major stimulator of inflammation and tissue remodeling at sites of Th2 inflammation, and common single-nucleotide polymorphisms in IL13 are associated with allergic phenotypes in several ethnically diverse populations. In particular, IL13Q110 is the non-conservative replacement of a positively charged arginine (R) with a neutral glutamine (Q) at position 110 of IL-13, and as we already...
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