Article
Genetic variants of IL-13 signalling and human asthma and atopy.
Human molecular genetics - 1 Mar 2000
Heinzmann A, Mao X Q, Akaiwa M, Kreomer R T, Gao P S, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts M H, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra C N, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin J M, Izuhara K, Shirakawa T, Deichmann K A
Abstract excerpt
Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (T(h)2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 receptor (IL-4R, a heterodimer of IL-4Ralpha and either gammac or IL-13Ralpha1) and IL-13 operates through IL-13R (a heterodimer of IL-4Ralpha and IL-13Ralpha1) to promote IgE synthesis and IgE-based mucosal inflammation which typify...
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