Article
Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.
Toxicology and applied pharmacology - 1 Nov 2000
Whetstine J R, Yueh M F, McCarver D G, Williams D E, Park C S, Kang J H, Cha Y N, Dolphin C T, Shephard E A, Phillips I R, Hines R N
Abstract excerpt
The flavin-containing monooxygenases (FMOs) are a family of xenobiotic-metabolizing enzymes that are expressed in a species- and tissue-specific manner. FMO2 expression has been observed in pulmonary tissue from several species, but not human. Two human FMO2 point mutations have been reported: a cytosine to thymidine transition at position 1414 resulting in a premature stop codon and a thymidine insertion at...
Topics
- Alleles
- Black People
- Blotting, Western
- Genotype
- Humans
- Oligonucleotides
- Oxygenases
- Polymorphism, Genetic
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- United States
- Black or African American