Article
Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2003
Lattard Virginie, Zhang Jun, Tran Quyen, Furnes Bjarte, Schlenk Daniel, Cashman John R
Abstract excerpt
To characterize the contribution of the human flavin-containing monooxygenase form 3 (FMO3) in the metabolism and disposition of drugs and xenobiotics, we determined the single nucleotide polymorphisms in the coding region and adjacent splice junctions of FMO3 in 134 African Americans and 120 Caucasians from the United States. In the regions examined, DNA resequencing or high throughput MassEXTEND studies coupled...
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