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Article

Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo

1 Jan 2004

Abstract excerpt

To analyze the biological role of factor XII (FXII, Hageman Factor) in vivo, we generated mice deficient for FXII using a gene targeting approach on two distinct genetic backgrounds, i.e. mixed C57Bl/6J X 129X1/SvJ and inbred 129X1/SvJ. Homozygous FXII knockout (FXII(-)/(-)) mice showed no FXII plasma activity and had a markedly prolonged activated partial thromboplastin time (aPTT). In contrast, coagulation...

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PMID: 15351846
DOI: 10.1160/th04-04-0250

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