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Article

Generation of genetically-altered mice producing very low levels of coagulation factorVII.

Thrombosis and haemostasis - 1 Sept 2005

Rosen Elliot D, Xu Haifeng, Liang Zhong, Martin J Andrew, Suckow Mark, Castellino Francis J

Abstract excerpt

It has been shown earlier that mice with a total targeted deletion of the factorVII gene (FVII(-/-)) die perinatally, thereby precluding study of adult animals with this total deficiency. Consequently, mice producing very low levels of FVII were developed by targeted replacement of the wild-type...

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PMID: 16268461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16268461-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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