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Article

The characterization of mice with a targeted combined deficiency of protein c and factor XI.

The American journal of pathology - 1 Feb 2001

Chan J C, Ganopolsky J G, Cornelissen I, Suckow M A, Sandoval-Cooper M J, Brown E C, Noria F, Gailani D, Rosen E D, Ploplis V A, Castellino F J

Abstract excerpt

Activated protein C functions directly as an anticoagulant and indirectly as a profibrinolytic enzyme. To determine whether the fibrin deposition previously observed in PC(-/-) murine embryos and neonates was mediated through the FXI pathway, PC(+/-)/FXI(-/-) mice were generated and crossbred to produce double-deficient progeny (PC(-/-)/FXI(-/-)). PC(-/-)/FXI(-/-) mice survived the early lethality observed in the...

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Source

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Identifiers

PMID: 11159184
DOI: 10.1016/S0002-9440(10)63989-2
PMCID: PMC1850297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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